Biophysics
Fragment Screen
Lead Generation
Medicinal Chemistry
Protein Expression
Protein Structure
Fragment Based Drug Discovery
Fragment Based Drug Discovery (FBDD), also known as Fragment Based Lead Discovery (FBLD) is a method in lead generation where a limited set of smaller molecules, fragments, are probed for binding to the target protein.
FBDD has emerged as an alternative to traditional HTS to identify initial chemistry starting points for drug discovery programs. Smaller molecules (fragments) have led to success in delivering novel leads for many different targets.
Service
Gene2Lead offers research service based on fast and efficient fragment based methods for lead generation.
We have the whole competence in house – and we are all there for you.
We deliver:
- Lead Generation
- Fragment Screen
- Protein Structure determination
- Medicinal Chemistry / Chemical Design
- Biophysics
- Protein Expression Optimization
Experience
The Gene2Leads research team has extensive drug development experience and has successfully delivered lead series and candidate drugs.
Gene2Lead
Gene2Leads research team has a long-standing industrial experience of drug discovery – especially structure based drug discovery. Our research and decision making is based on experimental data, not predictive models.
We are a fully equipped drug discovery unit with abilities from target expression to delivery of a bespoke lead series ready to enter lead optimization.
Proprietary technologies for protein production and high throughput X-ray crystallography are integrated with state-of-the-art medicinal chemistry capabilities to create a productive platform for the delivery of high-quality leads.
We operate in a tight format at the Karolinska Institute and KTH campus, with close links between disciplines and a project form with short-term decision points guiding our work.
Gene2Lead is powered by Sprint Bioscience, a drug discovery company with an oncology portfolio.
Working with us
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Industry experience combined with flexibility, commitment and the innovative spirit of a small company.
Objectives are mutually agreed.
Detailed project plan put in place.
Execution of project plan, with regular feedback.
Project delivery.
Continued support if required.
